医生理学講座 Medical Physiology

The 1st Joint Meeting of ISFP and PA Workshop

Tetsumei Urano, MD, PhD

Professor,

Department of Medical Physiology,

Hamamatsu University School of Medicine

 

Born: February 02, 1956

Place of Birth: Mie, Japan

Nationality: Japanese

Sex: Male

 

Education & Occupation:

Finished Ise High School, March, 1974.

Admitted to Hamamatsu University School of Medicine, April, 1975.

Finished same March, 1981.

Admitted to Graduate School, Hamamatsu University School of Medicine  (Majored in Surgery and Physiology), April, 1981.

Passed 71st National Examination for Medical Practitioners and received license for medical practice (#257349), May 1981.

Graduated from Graduate School of Hamamatsu University School of Medicine, and received Doctor of Medical Science, March, 1985.

Belonged to the Second Department of Surgery (Prof. S. Sakaguchi) of Hamamatsu University School of Medicine, April, 1985.

Joined Dr. Castellino's Laboratory in University of Notre Dame in USA as a post doctoral fellow, July, 1986.

Finished post doctoral course in the same laboratory, August, 1988.

Belonged to the Second Department of Physiology (Prof. A. Takada) of Hamamatsu University School of Medicine as an assistant, August, 1988.

Joined Dr. Tor Ny’s Laboratory as a visiting scientist sponsored by Japanese Government, June, 1990.

Joined Dr. Sixtus Thorsen's Laboratory as a visiting scientist sponsored by Japanese Government, March, 1991.

Associate Professor in Department of Physiology, Hamamatsu University School of Medicine, October, 1991.

Professor in Department of Physiology, Hamamatsu University School of Medicine, April, 2001.

 

List of Publication:

Original articles

1. Takada, A., Urano, T. and Takada, Y.   Influence of coagulation on the activation of plasminogen by streptokinase and urokinase.   Thrombos. Haemostas.   42(3): 901-908, 1979.

2. Takada, A., Matsuda, H., Urano, T. and Takada, Y.  Thrombin accelerating factor in various urokinase preparations.   Thromb. Res.   14(4/5): 673-678, 1979.

3. Urano, T. Takada, Y. and Takada, A.   The enhanced activation of Glu- and Lys-plasminogen by urokinase in the presence of fibrin or Des A Fibrin as measured by the release of Bß peptide and FDP.   Thromb. Res.   36(5): 429-435, 1984.

4. Urano, T., Kamiya, T., Sakaguchi, S., Takada, Y. and Takada, A.   Fibrinogenolysis and fibrinolysis in normal volunteers and patients with thrombosis after infusion of urokinase.   Thromb. Res.    39(2): 145-155, 1985.

5. Urano, T., Chibber, B. A. K. and Castellino, F. J.   The reciprocal effects of e-aminohexanoic acid and chloride ion on the activation of human (Glu1) plasminogen by human urokinase.   Proc. Natl. Acad. Sci.   USA  84: 4031-4034, 1987.

6. Urano, T., de Serrano, V. S., Chibber, B. A. K. and Castellino, F. J.   The control of the urokinase-catalyzed activation of human glutamic acid 1-plasminogen by positive and negative effectors.   J. Biol. Chem.   262(33): 15959-15964, 1987.

7. Urano, T., Urano, S. and Castellino, F.J.   Reaction of tissue-type plasminogen activator with 4-methylumbelliferyl-p-guadinino benzoate hydrochloride.   Biochim. Biophys. Res. Comm.   150(1): 45-51, 1988.

8. Castellino, F. J., Urano, T., de Serrano, V. S., Morris, J. P. and Chibber, B. A. K.   Control of human plasminogen activation.   Haemostas   18: suppl. 1, 15-23, 1988.

9. Gaffney, P. J., Urano, T., de Serrano, V. S. Mahmoud-Alexandroni, M., Metzer, A. R. and Castellino, F. J.   Roles for chloride ion and fibrinogen in the activation of [Glu1] plasminogen in human plasma. Proc. Natl. Acad. Sci.   85: 3595-3598, 1988.

10. Urano, T., de Serrano, V. S. Gaffney, P. J. and Castellino F. J.   Activation of human [Glu1] plasminogen by human single chain urokinase.   Arch Biochem. Biophys.   264: 222-230, 1988.

11. Urano, T., de Serrano, V. S. Gaffney, P. J. and Castellino F. J.   Effectors of the activation of human [Glu1] plasminogen by human tissue plasminogen activator.   Biochemistry   27:  6522-6528, 1988.

12. de Serrano, V. S., Urano, T., Gaffney, P. J. and Castellino F. J.   Influence of various structural domains of fibrinogen and fibrin on the potentiation of plasminogen activation by recombinant tissue plasminogen activator.   J. Protein Chem.   8(1) 61-77, 1989.

13. Urano, T., de Serrano, V. S., Urano, S. and Castellino, F. J.   Stimulation by fibrinogen of the amidolytic activity of single-chain tissue plasminogen activator.   Arch Biochem. Biophys.   270(1): 356-362, 1989.

14. Sakakibara K., Urano T., Takada Y., and Takada A.   Urinary UK, t-PA and urinary trypsin inhibitor in health and glomerular diseases.  Thromb. Res.   56; 239-249, 1989.

15. Urano T., Sakakibara K., Rydzewski A., Urano S., Takada Y. and Takada A.   Relationships between euglobulin clot lysis time and the plasma levels of tissue plasminogen activator inhibitor 1.   Thrombos. Haemostas.   63; 82-86, 1990

16. Sakakibara K., Urano T., Takada Y., and Takada A.   Significance of urinary complement components in various glomerular diseases.  Thromb. Res.   57; 625-637, 1990.

17. Takada A., Takada Y., Urano T., Sakakibara K. and Rydzewski A.   Fluctuations of euglobulin lysis time, tissue plasminogen activator, and free and total plasminogen activator inhibitor levels in plasma in daytime.  Thromb. Res.   57; 13-20, 1990.

18. Rydzewski, K. Sakata, A. Kobayashi, N. Yamazaki, T. Urano, Y. Takada and A. Takada.  Changes in plasminogen activator inhibitor 1 and tissue-type plasminogen activator during exercise in patients with coronary artery disease.  Haemostasis   20(5): 305-312, 1990

19. T Urano, K Sumiyoshi, M Nakamura, T Mori, Y Takada and A Takada.   Fluctuation of tPA and PAI-1 antigen levels in plasma. : Difference of their fluctuation patterns between male and female.  Thromb. Res.   60(2); 133-139, 1990

20. Pietraszek, M. H., Choudhury, N. A., Koyano, K., Sakaguchi, S., Kamiya, T., Urano, T., Takada, Y. and Takada, A.   Enhanced platelet responce to serotonin in Buerger's disease.   Thromb. Res.   60;241-246, 1990.

21. Pietraszek, M. H., Urano, T., Serizawa, K., Takahashi, S., Sumiyoshi, K., Takada, Y. and Takada, A.   Circadian rhythm of serotonin : Influence of age.   Thromb. Res.   60;253-257, 1990.

22. T Urano, M. Cho, S. Takahashi, K. Sumiyoshi, M. Nakamura, T. Mori, Y Takada and A Takada.  Changes of parameters in fibrinolytic system caused by mental stress.   Thromb. Res.   60; 501-507, 1990.

23. Takada, A., Takada, Y., Urano, T., Sakakibara, K., Shozuhara, H., Toyama, K.  Changes in plasma levels of t-PA, PAI-1 and t-PA-PAI-1 complex in patients with cerebrovascular thrombosis infused with t-PA.  Thromb. Res.   59(2);375-381, 1990

24. Takada, A., Urano, T., Takada, Y.  The regulation of the activation of the fibrinolysis system. [Review]  Advances in Experimental Medicine & Biology  281(209), 209-222, 1990.

25. Urano, T., Takada, Y. and Takada, A.   Effects of N-terminal peptide of Glu-plasminogen on the activation of Glu-plasminogen and its conversion to Lys-plasminogen.   Thromb. Res.   61; 349-359, 1991.

26. T. Urano, Y. Takada and A. Takada.   Stimulation of the amidolytic activity of single chain tissue-type of plasminogen activator by fibrinogen degradation products : possible binding sites on single chain tissue plasminogen activator molecule.   Biochim. Biophys. Acta   1077; 245-252, 1991.

27. Urano, T. Sumiyoshi, K. Pietraszek, M. H. Takada, Y. and Takada, A.   PAI-1 plays an important role in the expression of t-PA activity in the euglobulin clot lysis by controlling the concentration of free t-PA.   Thrombos. Haemostas.   66(4) 474-478, 1991

28. M. Pietraszek, T. Urano, K. Sumiyoshi, K. Serizawa, S. Takahashi, Y. Takada and A. Takada.   Alcohol-induced depression : Involvement of serotonin.   Alcohol & Alcoholism   26(2), 155-159, 1991

29. Kawamura, I. Watanabe, T. Urano, Y. Takada and A. Takada.   The effects of polysaccharides on plasminogen activation by single chain-tissue plasminogen activator.   Thromb. Res.   62, 481-490, 1991

30. Sumiyoshi, S. Baba, S. Sakaguchi, T. Urano, Y. Takada and A. Takada.   Increase in levels of plasminogen activator and type-1 plasminogen activator inhibitor in human breast cancer: possible roles in tumor progression and metastasis.   Thromb. Res.   63, 59-71, 1991

31. Sumiyoshi, K. Serizawa, T. Urano, Y. Takada, A. Takada and S. Baba.   Plasminogen activator system in human breast cancer.   Int. J. Cancer   50, 345-348, 1992.

32. Pietraszek, M.H., Urano, T., Sumiyoshi, K., Takada, Y., Takada, A., Ohara, K., Kondo, N., Ohara, K.   Diurnal variations of whole blood serotonin content in patients with depression and neurosis.   Journal of Neurology, Neurosurgery & Psychiatry  55(4) 336-337, 1992.

33. Pietraszek, M.H., Takada, Y., Yan, D., Urano, T., Serizawa, K., and Takada, A.  Relationship between serotonergic measures in periphery and the brain of mouse.  Life Science  51 75-82, 1992

34. Urano T., Strandberg L., Johansson L. B-A., Ny T.  A substrate-like form of plasminogen activator inhibitor type 1: Conversions between different forms by sodium dodecyl sulphate.  Eur. J. Biochem.  209, 985-992, 1992

35. Pietraszek M.H., Yan, D., Urano, T., Sakakibara, K., Serizawa, K., Takada, Y. and Takada, A.  Correlations between serotonin and related substances simultaneously obtained from rat brain and blood.  Biogenic Amines.  9(2) 123-129, 1992

36. Sakata, K., Hoshino, T., Yoshida, H., Ono, N., Ohtani, S., Yokoyama, S., Mori, N., Kaburagi, T., Kurata, C., Urano, T., Takada, Y. and Takada, A.  Circadian fluctuations of tissue plasminogen activator antigen and plasminogen activator inhibitor-1 antigens in vasospastic angina.  Am. Heart J. 124(4): 854-860, 1992

37. Yan, D., Urano, T., Takada, Y. and Takada, A.  Dissociation of a2-plasmin-inhibitor-plasmin complex and regeneration of plasmin activity by SDS treatment.  Thromb. Res.   69, 491-499, 1993.

38. Yan, D., Urano, T., Pietraszek, M.H., Shimoyama, I., Uemura, K., Kojima, Y., Sakakibara, K., Serizawa, K., Takada, Y. and Takada, A. Correlation between serotonergic measures in cerebrospinal fluid and blood of subhuman primate.  Life Science  52, 745-749, 1993

39. Kozima, Y., Urano, T., Sakakibara, K., Serizawa, K., Takada, Y. and Takada, A. Impaired Fibrinolytic Activity Induced by Ingestion of Butter : Effect of Increased Plasma Lipid on the Fibrinolytic Activity.  Thromb. Res. 70; 191-202, 1993

40. Urano, T., Kojima, Y., Takahashi, M., Serizawa, K., Sakakibara, K., Takada, Y. and Takada, A.  Impaired fibrinolysis in hypertension and obesity due to high plasminogen activator inhibitor-1 level in plasma.  Jpn. J. Physiol. 43, 221-228, 1993

41. Takada, Y., Urano, T. and Takada, A.  Conformational change of plasminogen: Effects of N-terminal peptides of Glu-plasminogen.  Thromb. Res.  70; 151-159, 1993

42. Pietraszek, M. H., Choudhury, N.A., Baba, S., Sakaguchi, S., Hachiya, T., Urano, T., Takada, Y., Takada, A.  Serotonin as a factor involved in pathophysiology of thromboangitis obliterans.  Int. Angiol.  12(1) 9-12, 1993

43. Serizawa, K., Urano, T., Kozima, Y. , Takada, Y. and Takada A. The potential role of platelet PAI-1 in t-PA mediated clot lysis of platelet rich plasma.  Thromb. Res.  71; 289-300, 1993

44. Mikus, P., Urano, T., Liljestöm, P., Ny, T.  Plasminogen activator inhibitor type 2 (PAI-2) is a spontaneously polymerizing SERPIN : Biochemical characterization of the recombinant intracellular and extracellular forms.  Eur. J. Biochem.  218, 1071-1082, 1993.

45. Takada, Y., Urano, T., Watanabe, I., Taminato, A., Yoshimi, T., Takada, A.  Changes in fibrinolytic parameters in male patients with type 2 (non insulin dependent) diabetes mellitus.  Thromb. Res.  71, 405-415, 1993.

46. Malyszko, J., Urano, T., Serizawa, K., Yan, D., Kozima, Y., Takada, Y. and Takada, A.  Serotonergic measures in blood and brain and their correlations in rats treated with tranylcypromine, a monoamine oxidase inhibitor.  Jpn. J. Physiol.  43, 613-626, 1993.

47. Malyszko, J., Urano, T., Yan, D., Serizawa, K., Kozima, Y., Takada, Y. and Takada, A.   Water-immersion restraint stress and serotonergic measures in blood and different areas of rat brain.  Biogenic Amines.  10, 111-118, 1994

48. Bashar, H., Urano, T., Fukuta, K., Pietraszek, M.H., Hata, M., Suzuki, K., Kawabe, K., Takada, T. and Takada, A.  Plasminogen activators and plasminogen activator inhibitor 1 in urinary tract cancer.  Urologia Internationalis  52, 4-8, 1994.

49. Nagayama, M., Sato, A., Hayakawa, H., Urano, T., Takada, Y. and Takada, A.  Plasminogen activators and their inhibitors in non-small cell lung cancer: Low content of type 2 plasminogen activator inhibitor associated with tumor dissemination.  Cancer 73(5), 1398-1405, 1994

50. Takada, Y., Urano, T. and Takada, A.  Effect of heparan sulfate analogue or other sulfated polysaccharides on the activation of plasminogen by t-PA or u-PA.  Thromb. Res.  73(5), 301-311, 1994

51. Malyszko, J., Urano, T., Takada, Y. and Takada, A.   Stress dependent changes in fibrinolysis, serotonin and platelet aggregation in rats.  Life Sci.  54(17): 1275-1280, 1994

52. Malyszko, J., Urano, T., Takada, Y. and Takada, A. Time-dependent changes in platelet aggregation, fibrinolytic activity, and peripheral serotnergic measures in rats subjected to water-immersion restraint stress.  Haemostasis  24, 236-242, 1994

53. Urano T., Malyszko J., Serizawa K., Kozima Y., Takada Y. and Takada A.  Electric-foot-shock induced the supression of fibrinolytic activity in rats.  Thromb. Res.  74(6): 595-603, 1994

54. Kojima, Y., Urano, T., Kojima, K., Serizawa, K., Takada, Y. and Takada, A.  The Significant Enhancement of Fibrinolysis by Calcium Ion in a Cell Free System. : The Shortening of Euglobulin Clot Lysis Time by Calcium Ion.  Thromb. Haemostas.  72(1), 113-118, 1994

55. Malyszko, J., Urano, T., Yan, D., Serizawa, K., Kozima, Y., Takada, Y. and Takada, A.  Foot shock-induced changes in blood and brain serotonin and related substances in rats.  Jpn. J. Physiol.  44, 35-47, 1994

56. Malyszko, J., Takada, Y., Urano, T.and Takada, A.     FK 506 affects platelet aggregation in vitro.   Thromb. Res. 75(1), 99-104, 1994

57. Malyszko, J., Takada, Y., Urano, T., Serizawa, K., Kozima, Y., Yan, D. and Takada, A.  Peripheral and central serotonergic systems in rats subjected to footshock or water-immersion restraint stress.  Biogenic Amines  10(4), 303-310, 1994

58. Malyszko, J., Urano, T., Takada, Y. and Takada, A.  Serotonergic systems in brain and blood under stress and tranylcypromine treatment in rats.  Brain Res. Bull.   35(1), 9-13, 1994

59. Malyszko, J., Urano, T., Takada, Y. and Takada, A.  Stress and/or tranylcypromine treatment affects serotonergic measures in blood and brain in rats.  Neuroscience Res.  19, 365-371, 1994

60. Urano, T., Serizawa, K., Takada, Y., Ny, T. and Takada, A.  Heparin and heparan sulphate enhancement of the inhibitory activity of plasminogen activator inhibitor type 1 toward urokinase type plasminogen activator.  Biochim. Byophys. Acta  1201, 217-222, 1994

61. Serizawa, K., Urano, T., Kojima, Y., Ihara, H., Takada, Y., Takeuchi, S. and Takada, A.  Medroxyprogesterone acetate (MPA) increases PAI-1 secretion from HUVEC and elevates the plasma levels of PAI-1 in vivo.  Oncology Report 1, 1127-1130, 1994

62. Malyszko, J., Urano, T., Knofler, R., Taminato, A., Yoshimi, T., Takada, Y. and Talkada, A.  Daily variations of platelet aggregation in relation to blood and plasma serotonin in diabetes.  Thromb. Res. 75(5), 569-576, 1994

63. Malyszko, J., Urano, T., Knofler, R., Ihara, H., Shimoyama, I., Uemura, K., Takada, Y. and Takada, A.  Correlation between platelet aggregation, fibrinolysis, peripheral and central serotonergic measures in subhuman primates. Atherosclerosis  110, 63-68, 1994

64. Malyszko, J., Urano, T., Knofler, R., Ihara, H., Takada, Y. and Takada, A.  Relationships between serum lipids, serotonin, platelet aggregation and some fibrinolytic parameters in humans.  Life Sciences  55(21), 1619-1623, 1994

65. Knofler, R., Urano, T., Takada, Y. and Takada, A.  N,N,N-Trimethylsphingosine modifies aggregatory response and ATP release from platelets in whole blood.  Thromb. Res. 76(4), 323-332, 1994

66. Aoki, K., Nishino, N., Baba, S., Urano, T. and Takada, A.  Postoperative changes in plasma tissue-type plasminogen activator and type 1 plasminogen activator inhibitor.  Surg Today Jpn J Surg 24, 1039-1043, 1994

67. Malyszko, J., Takada, Y., Urano, T., Ihara, H., Serizawa, K., Kozima, Y. and Takada, A.  Relationship between cholesterol and serotonergic measures in rats subjected to different stresses.   Biogenic Amines 10(5): 465-471, 1994

68. Malyszko, J., Urano, T., Ihara, H., Takada, Y. and Takada, A.  Central and peripheralserotonergic systems under stress and/or administration of DV-7028, a novel 5HT2 receptor blocker, in rats.  J. Serotonin Res. 1(2): 133-141, 1994

69. Malyszko, J., Urano, T., Ihara, H., Takada, Y. and Takada, A.  Platelet aggregation, fibrinolytic and peripheral serotonergic systems following administration of DV-7028, a novel serotonin (5HT)2  receptor antagonist.  J. Serotonin Res.  1(2): 163-168, 1994

70. Takada, A., Takada, Y., Urano, T., Hishida, A., Ohara, Ko. and Ohara, Ke. Relationship between serum lipids and plasma or blood serotonin levels in normal volunteers and nephrotic and depressive patients. J. Serotonin Res. 1(3): 221-227, 1994

71. Malyszko, J., Urano, T., Hishida, A., Taminato, T., Takada, A. and Takada, Y.  Lipids and serotonin: a possible link? Nephrol. Dial. Tansplant. 9: 1353-1354, 1994

72. Takada, A., Takada, Y. and Urano, T. The physiological aspects of fibrinolysis. Thromb. Res. 76(1); 1-31, 1994. (Review)

73. Malyszko, J., Urano, T., Takada, Y. and Takada, A.  Amino acids, serotonin, and 5-hydroxyindoleacetic acid following foot shock in rats.  Brain Res. Bull. 36(2): 137-140, 1995

74. Kotani, I., Sato, A., Hayakawa, H., Urano, T., Takada, Y. and Takada, A.  Increased procoagulant and antifibrinolytic activities in the lungs with idiopathic pulmonary fibrosis.  Thromb. Res.  77(6), 493-504, 1995

75. Knofler, R., Urano, T., Malyszko, J., Takada, Y. and Takada, A.  In vitro effect of endothelin-1 on collagen, and ADP-induced aggregation in human whole blood and platelet rich plasma.  Thromb. Res.  77(1), 69-78, 1995

76. Wu, K., Urano, T., Ihara, H., Takada, Y., Fujie, M., Shikimori, M., Hashimoto, K. and Takada, A.  The Cleavage and Inactivation of Plasminogen Activator Inhibitor Type 1 by Neutrophil Elastase: The Evaluation of Its Physiological Relevance in Fibrinolysis.  Blood  86, 1056-1061, 1995

77. Urano, T., Malyszko, J., Takada, Y and Takada, A. Close relationships between serotonergic and fibrinolytic systems revealed by a mono-amine-oxidase inhibitor treatment in rats.  Haemostasis  25, 277-282, 1995

78. Urano, T., Mori, T., Takada, Y. and Takada, A. Absence of synergism in the activity of tissue plasminogen activator and urinary plasminogen activator measured by clot lysis time.  Turk J Haematol. 14, 3-7, 1995

79. Mugiya, S., Suzuki, K., Ueda, D., Ohtawara, Y., Fujita, K., Malyszko, J., Urano, T., Knofler, R., Takada, Y. and Takada, A. Renal blood flow, fibrinolysis, and platelet aggregation following tacrolimus (FK506) treatment in rats.  Thromb Res. 79(3), 337-341, 1995

80. Malyszko, J., Takada, Y., Yan, D., Ihara, H., Urano, T. and Takada, A.  Effects of Y-25130, a novel 5HT3 receptor antagonist, on peripheral and central serotonergic systems in rats.  Journal of Serotonin Research, 1995 2 85-89.

81. Knöfler, R., Takada, Y., Ihara, H., Urano, T. and Takada, A. Effects of nicotine and electric ftootshock on peripheral serotonergic measures and on platelet aggregation in whole blood of rats.  Life Sci. 57(4): 363-369, 1995

82. Takada, Y., Ihara, H., Urano, T. and Takada, A.  Changes in blood and plasma serotonergic measurements in rats administered with nicotine and/or exposed to different stresses.  Thromb. Res. 80(4): 307-316, 1995

83. Knöfler, R., Urano, T., Taminato, T., Yoshimi, T., Nakano, T., Nakajima, K., Takada, Y. and Takada, A.  Daily variation of serum lipids in relation to the circadian rhythm of platelet aggregation in healthy male persons.  Clin. Chim.Acta 239: 109-119, 1995

84. Takada, Y., Urano, T., Ihara, H. and Takada, A.  Changes in central and peripheral serotonergic system in rats exposed to water-immersion restrained stress and nicotine administration. Neurosci. Res. 23: 305-311, 1995

85. Urano, T., Takada, Y., Ihara, H. and Takada, A. Reexamination of the extent of the activation of lys78-plasminogen by tissue plasminogen activator in the presence of polymerized fibrin.  Haemostasis, 26, 220-227, 1996

86. Takada Y., Urano, T., Malyszko, J. and Takada, A. Changes in Serotonergic Measures in Whole Blood and Various Brain Regions of Rats Administered With the 5-HT1A Agonist Tandospirone and/or Exposed to Electric Foot Shock.  Brain Research Bulletin, 40(1), 51-55, 1996

87. Mochizuki M., Takada Y., Urano T., Nagai N., Nakano T., Nakajima K. and Takada A.  The in vitro effects of chylomicron remnant and very low density lipoprotein remnant on platelet aggregation in blood obtained from healthy persons.  Thromb Res. 81(5), 583-593, 1996

88. Malyszko J., Urano T., Knöfler R., Takada Y. and Takada A.  Effects of short term treatment with mevalotin on platelet aggregation, fibrinolysis, peripheral serotonergic system and serum lipids in Japanese monkeys.  Thromb. Res.  81(2), 397-402, 1996

89. Urano T., Ihara H., Takada Y., Nagai N. and Takada A.  The inhibition of human factor Xa by plasminogen activator inhibitor type 1 in the presence of calcium ion, and its enhancement by heparin and vitronectin.  Biochim. Biophys. Acta  1298, 199-208, 1996

90. Rydzewski, A., Urano, T., Hachiya, T., Kaneko, H., Baba, S., Takada, Y. and Takada, A.  The effect of a 5HT2 receptor antagonist sarpogrelate (MCI-9042) treatment on platelet function in Buerger's disease.  Thromb. Res.  84(6), 445-452, 1996

91. Urano, T., Wu, K., Ihara, H., Takada, Y., Takada, A.  Novel mechanism to enhance tPA-induced fibrinolysis: effect of limited proteolysis of PAI-1 by neutrophil elastase.  Polish Journal of Pharmacology  48(2), 209-213, 1996

92. Takada, A., Urano, T., Yoshida, M., Takada, Y.  Comparison of changes in serotonergic measures in whole blood or plasma and brain in rats given nicotine and/or stresses.  Polish Journal of Pharmacology 48(2), 173-177, 1996

93. Takahashi, H., Urano, T., Takada, Y., Nagai, N. and Takada.  Fibrinolytic parameters as an admission prognostic marker of head injury in patients who talk and deteriorate.  J. Neurosurgery  86, 768-772, 1997

94. Takada, Y., Takahashi, H., Ihara, H., Urano, T. and Takada, A.  Effects of Nicotine on serotonergic systems of brain and blood of rats exposed to footshock.  Biogenic Amines  13(1), 67-78, 1997

95. Urano, T., Nishikawa, T., Nagai, N., Takada, Y. and Takada, A.  Amounts of tPA and PAI-1 in the euglobulin fraction obtained at different pH: Their relation to the euglobulin clot lysis time.  Thromb. Res. 88(1), 75-80, 1997

96. Takada, Y., Takada, A. and Urano, T. MCI-9042, the new selective antagonist of serotonergic (5-HT2A) receptors.  Cardiovascular Drug Reviews 15(2): 101-121, 1997

97. Imokawa, S., Sato, A., Hayakawa, H., Kotani, M., Urano, T., Takada, A.  Tissue factor expression and fibrin deposition in the lungs of patients with idiopathic pulmonary fibrosis and systemic sclerosis.  American Journal of Respiratory & Critical Care Medicine, 156(2 Pt1):631-6, 1997

98. Rydzewski, A., Urano, T., Nagai, N., Takada, Y., Katoh-Oishi, Y., Taminato, T., Yoshimi, T. and Takada, A. Diurnal variation in serum remnant-like lipoproteins, platelet aggregation and fibrinolysis in healthy volunteers.  Haemostasis, 27, 305-314, 1997

99. Nagai, N., Urano, T., Takada, Y. and Takada, A.  Reperfusion after venous occlusion caused transient increase in plasminogen activator inhibitor-1 in systemic circulation. Clinical and Applied Thrombosis/Hemostasis, 4(2), 133-137, 1998

100. Takahashi, H., Takada, Y., Nagai, N., Urano, T. and Takada, A. Nicotine increases stress-induced serotonin release by stimulating nicotinic acetylcholine receptor in rat striatum.  Synapse, 28: 212-219, 1998

101. Takahashi, H., Takada, Y., Nagai, N., Urano, T. and Takada, A.  Extracellular serotonin in the striatum increased after immobilization stress only in the nighttime.  Behave. Brain Res. 91: 185-191, 1998

102. Takahashi, H, Takada, Y., Nagai, N., Urano, T. and Takada, A.  Effects of nicotine and foot-shock stress on dopamine release in the striatum and nucleus accumbens.  Brain Res. Bull.  45, 157-162, 1998

103. Takada, Y., Nagai, N., Takahashi, H., Urano, T. and Takada, A.  Increased serotonergic activities inhibit feedings and cause arousal responses in rats.  Biogenic Amines  14(1): 67-77, 1998

104. Urano, T., Nagai, N., Matsuura, M., Ihara, H., Takada Y. and Takada, A. Human thrombin and calcium bound factor Xa significantly shorten tPA-induced fibrin clot lysis time via neutralization of plasminogen activator inhibitor type 1 activity.  Thromb Haemost  80, 161-166, 1998

105. Takahashi, H., Urano, T., Nagai, N., Takada, Y. and Takada, A.  Hyperfibrinolytic Activity After Head Injury Is Induced By Elevated tPA Activity.  Fibrinolysis and Proteolysis  12(2), 113-118, 1998

106. Aoki, K., Yoshino, A., Ueda, Y., Urano, T. and Takada, A.  Severe heat stroke associated with high plasma levels of plasminogen activator inhibitor 1.  Burns  24, 74-77, 1998

107. Morita, S., Sato, A.,  Hayakawa, H., Ihara, H., Urano, T., Takada, Y. and Takada A.  Cancer Cells Overexpress mRNA of Urokinase-Type Plasminogen Activator, Its Receptor And Inhibitors In Human Non-Small-Cell Lung Cancer Tissue: Analysis By Northern Blotting And In Situ Hybridization.   Int J Cancer  78, 286-292, 1998

108. Takahashi, H., Urano, T., Nagai, N., Takada, Y. and Takada, A.  Progressive expansion of hypertensive intracerebral hemorrhage by coagulopathy.  Am. J. Hematology  59, 110-114, 1998

109. Endo, A., Nagai, N., Urano, T., Ihara, H., Takada, Y. and Takada, A.  Proteolysis of highly polysialylated NCAM by the tissue plasminogen activator-plasmin system in rats.  Neuroscience Letters, 246, 37-40, 1998.

110. Takada, Y., Urano, T., Takahashi, H., Nagai, N. and Takada, A.  Effects of electric footshock and water immersion restraint stresses on fibrinolytic parameters in the plasma of rats.  Thromb. Res. 89, 107-114, 1998.

111. Teramoto, Y., Urano, T., Nagai, N., Takada, Y., Ikeda, K. and Takada, A.  Plasma Levels of 5-HT and 5-HIAA increased after Intestinal Ischemia/Reperfusion in Rats.   Jpn. J. Physiol.  48, 333-339, 1998

112. Endo, A., Nagai, N., Urano, T., Takada, Y., Hashimoto, K. and Takada, Y.  Proteolysis of neuronal cell adhesion molecule by the tissue plasminogen activator-plasmin system after kainate injection in the mouse hippocampus.  Neuroscience Research  33, 1-8, 1999

113. Nagai, N., Urano, T., Endo, A., Takahashi, H., Takada, Y. and Takada, A.  Neuronal degeneration and a decrease in laminin-like immunoreactivity is associated with elevated tissue-type plasminogen activator  in the rat hippocampus after kainic acid injection.  Neuroscience Research  33, 147-154, 1999

114. Ahaneku, J.E., Sakata, K., Urano, T., Takada, Y. and Takada, A.  Influence of baseline values on lipids, lipoproteins and fibrinolytic parameters during treatment of hypertension with cilnidipine.  Pharmacological Research  41(1), 81-84, 2000

115. Ahaneku, J.E., Sakata, K., Urano, T., Takada, Y. and Takada, A.  Influence of baseline values on lipids, lipoproteins and fibrinolytic parameters during amlodipine treatment of hypertension in Japanese.  Pharmacological Research  41(1), 75-79, 2000

116. Sakata, K., Shirotani, M., Yoshida, H., Urano, T., Takada, Y. and Takada, A.  Differential effects of analapril and nitrendipine on the fibrinolytic system in essential hypertension.  Am. Heart J.  137 (6), 1094-1099, 1999

117. Abe, J., Urano, T., Konno, H., Erhan, Y., Tanaka, T., Nishino, N., Takada, A. and Nakamura, S. Larger and more invasive colo-rectal cancer contained larger amounts of plasminogen activator inhibitor type 1 and its relative ratio over urokinase receptor correlated well with tumor size.  Cancer  86(12), 2602-2611, 1999

118. Urano, T., Ihara, H., Suzuki, Y., Takada, Y. and Takada. A.  Coagulation Associated Enhancement of Fibrinolytic Activity Via a Neutralization of PAI-1 Activity.  Semin. Thromb. Hemost. 26(1), 39-42, 2000

119. Urano, T., Ihara, H., Takada, Y., Fujie, M. and Takada, A.  The cleavage and inactivation of plasminogen activator inhibitor type 1 and 2-antiplasmin by reptilase, a thrombin-like venom enzyme.  Blood Coagulation & Fibrinolysis  11(2), 145-153, 2000

120. Pawlak, R., Takada, Y., Takahashi, H., Urano, T., Ihara, H., Nagai, N. and Takada, A.  Differential effects of nicotine against stress-induced changes in dopaminergic system in rat striatum and hippocampus.  Eur. J. Pharamacol.  387, 171-177, 2000

121. Urano, T., Ihara, H., Suzuki, Y., Nagai, N., Takada, Y. and Takada, A.  Soluble thrombomodulin quenches thrombin-mediated neutralization of PAI-1 activity and inhibits fibrinolysis through a TAFI independent mechanism.  Fibrinolysis & Proteolysis  13(6), 264-271, 1999

122. Fujii, M., Hayakawa, H., Urano, T., Sato, A., Chida, K., Nakamura, H. and Takada, A.  Relevance of tissue factor and tissue factor pathway inhibitor for hypercoagulable state in the lungs of patients with idiopathic pulmonary fibrosis.   Thromb. Res.  99, 111-117, 2000

123. Takahashi, H., Urano, T., Takada, Y., Nagai, N. and Takada, A.  Neutrophil Elastase May Play a Key Role in the Development of Symptomatic DIC and Multiple Organ Failure in Patients with Head Injury.  J. Trauma  49, 86-91, 2000

124. Pawlak D, Takada Y, Urano T and Takada A.  Serotonergic and kunurenic pathways in rats exposed to foot shock.  Brain Res. Bull.  52(3), 197-205, 2000

125. Takahashi, H., Takada, Y., Nagai, N. Urano, T., and Takada, A.  Previous exposure to footshock stress attenuates nicotine-induced serotonin release in rat striatum during the subsequent stress.  Brain Res. Bull.  52(4), 285-290, 2000

126. Takahashi, H., Takada, Y., Nagai, N. Urano, T., and Takada, A.  Serotonergic neurons projecting to hippocampus activate locomotion.  Brain Res  869, 194-202, 2000

127. Sakai, T., Kyogashima, M., Kariya, Y., Urano, T., Takada, Y. and Takada, A.  Importance of GlcA1-3GalNAc(4S,6S) in Chondroitin Sulfate E for t-PA- and u-PA- Mediated Glu-plasminogen Activation.  Thromb Res 100(6) 557-565, 2000

128. Ahaneku J.E., Sakata K., Urano T., Takada Y. and Takada A.  Lipids, lipoproteins and fibrinolytic parameters during amilodipine treatment of hypertension.  J. Health Sci.  46(6), 455-458, 2000

129. Suzuki, Y., Urano, T., Ihara, H., Nakajima, T., Nagai, N., Takada, Y., Taminato, T. and Takada, A.  Bezafibrate attenuates the overexpression of plasminogen activator inhibitor-1 messenger RNA by a combination of mono-unsaturated fatty acid and insulin in HepG2 cells.  Life Science  68 1827-1837, 2001

130. Ihara, H., Urano, T., Takada, A. and Loskutoff D. J.  Induction of plasminogen activator inhibitor-1 (PAI-1) gene expression in adipocytes by thiazolidinediones.  FASEB J. 15(7):1233-1235, 2001

131. Urano T., Suzuki Y., Arakida M., Kanamori M. and Takada A.  The expression of exercise-induced tPA activity in blood is regulated by the basal level of PAI-1.  Thromb. Haemost.  85, 751-752, 2001

132. Nagai N., Yamamoto S., Tsuboi T., Ihara H., Urano T., Takada Y., Terakawa S. and Takada A.   Tissue-type plasminogen activator enhances neuronal death induced by oxygen-glucose-deprivation in culture.  J Cereb Blood Flow Metab. 21(6): 631-634. 2001

133. Urano T., Ihara H., Umemura K., Suzuki Y., Oike M., Akita S., Tsukamoto Y., Suzuki I. and Takada A.  The profibrinolytic enzyme subtilisin NAT purified from Bacillus subtilis cleaves and inactivates plasminogen activator inhibitor type 1.  J Biol Chem 276(27): 24690-24696, 2001

134. Takahashi H, Takada Y, Urano T, Takada A. Dissociation of systemic and hippocampal modulation of rat locomotor activity by 5-HT(2C) receptors.  Neurosci Res. 40(1): 97-103, 2001

135. Konno H, Abe J, Kaneko T, Baba M, Shoji A, Sunayama K, Kamiya K, Tanaka T, Suzuki S, Nakamura S, Urano T.  Urokinase receptor and vascular endothelial growth factor are synergistically associated with the liver metastasis of colorectal cancer. Jpn J Cancer Res. 92(5): 516-523, 2001

136. Pawlak R, Napiorkowska-Pawlak D, Takada Y, Urano T, Nagai N, Ihara H, Takada A. The differential effect of angiotensin II and angiotensin 1-7 on norepinephrine, epinephrine, and dopamine concentrations in rat hypothalamus: the involvement of angiotensin receptors.  Brain Res Bull.  54(6): 689-694, 2001

137. Yoshino A, Suzuki K, Urano T, Aoki K, Takada Y and Takada A  Enhanced secretion of tissue plasminogen activator by simultaneous use of retinoic acid and ascorbic acid from tissue cultured gastroepiploic artery.  Life Sciences 70, 1461-1470, 2002

138. Aoki K, Aikawa N, Sekine K, Yamazaki M, Mimura T, Urano T and Takada A.  Elevation of plasma free PAI-1 levels as an integrated endothelial response to severe burs.  Burns  27, 569-575, 2001

139. Pawlak R¬, Nagai N, Urano T, Napiorkowska-Pawlak D, Ihara H, Takada Y , Collen D. and Takada A.  Rapid, specific and active site-catalyzed effect of tissue-plasminogen activator on hippocampus-dependent learning in mice.  Neuroscience  113(4), 995-1001, 2002

140. Yoshida M, Naito Y, Urano T, Takada A and Takada Y.  L-158,809 and (D-Ala7)-angiotensin I/II (1-7) decrease PAI-1 release from human umbilical vein endothelial cells.  Thromb. Res. 105(6), 531-536, 2002

141. Nagai N, Zhao BQ, Suzuki Y, Ihara H, Urano T, Takada A, Umemura K. Tissue-type plasminogen activator has paradoxical roles in focal cerebral ischemic injury by thrombotic middle cerebral artery occlusion with mild or severe photochemical damage in mice.  J Cereb Blood Flow Metab. 22, 648-651, 2002

142. Suzuki Y, Kondo K, Ichise H, Tsukamoto Y, Urano T and Umemura. K.  Dietary supplementation with fermented soybeans suppresses intimal thickening.    Nutrition. 19 (3), 261-264, 2003

143. Sakata K, Pawlak R, Urano T and Takada A  Effects of a longterm pharmacological interruption of the rennin-angiotensin system on the fibrinolytic system in essential hypertension.  Pathophysiology of Haemostasis and Thrombosis.  32, 67-75, 2002

144. Takahashi H, Takada Y, Urano T and Takada A.  5-HT4 receptors in the hippocampus modulate rat locomotor activity.  Hippocampus 12, 304-310, 2002

145. Mogami H, Zhang H, Suzuki Y, Urano T, Saito N, Kojima I, and Petersen OH.  Decoding of short-lived Ca2+influx signals into long-term substrate phosphorylation through activation of two distinct classes of protein kinase C.  J. Biol. Chem.  278(11), 9896-9904, 2003

146. Suzuki Y, Kondo K, Matsumoto Y, Zhao BQ, Otsuguro K, Maeda T, Tsukamoto Y, Urano T, Umemura K.  Dietary supplementation of fermented soybean, natto, suppresses intimal thickening and modulates the lysis of mural thrombi after endothelial injury in rat femoral artery. Life Sci 73(10), 1289-98, 2003

147. Urano T, Castellino FJ, Ihara H, Suzuki Y, Ohta M, Suzuki K, Mogami H. Activated protein C attenuates coagulation-associated over expression of fibrinolytic activity by suppressing the thrombin-dependent inactivation of PAI-1.  Journal of Thrombosis and Hemostasis  1, 2615-2620, 2003

148. Zhao BQ, Ikeda Y, Ihara H, Urano T, Fan WY, Mikawa S, Suzuki Y, Kondo K, Sato K, Nagai N and Umemura K.  Essential role of endogenous tissue plasminogen activator through matrix metalloproteinase 9 induction and expression on heparin-produced cerebral hemorrhage after cerebral ischemia in mice.  Blood  103(7), 2610-2616, 2004

149. Takahashi T, Suzuki K, Ihara H, Mogami H, Kazui T and Urano T. Plasminogen activator inhibitor-1 promotes fibrosarcoma cell migration by modifying cellular attachment to vitronectin via vb5 integrin.  Semin Thromb Hemost.  31(3), 356-363, 2005

150. Hryszko T, and Urano T. Activated Protein C enhances tPA-catalyzed Glu-plasminogen activation in the presence of poly-D-lysine. Thrombosis & Haemostasis 92(4), 891-2, 2004

151. Takahashi H, Nagai N and Urano T. Role of tissue plasminogen activator/plasmin cascade in delayed neuronal death after transient forebrain ischemia.  Neuroscience Letters  381, 189-193, 2005

152. Inaba K, Suzuki S, Ihara H, Sakaguchi T, Baba S, Urano T, Konno H, Nakamura S.  Sexual dimorphism in endotoxin susceptibility after partial hepatectomy in rats.  J Hepatol  42(5), 719-27, 2005

153. Terada H, Urano T, Konno H. Association of interleukin-8 and plasminogen activator system in the progression of colorectal cancer.  Eur. Surg. Res. 37, 166-172, 2005

154. Hryszko T, Inaba K, Ihara H, Suzuki Y, Mogami H, Urano T.  Nafamostat attenuated the impairment of fibrinolysis in animal sepsis model by suppressing the increase of plasminogen activator inhibitor type 1.  The Journal of Trauma, Injury, Infection and Critical Care  60(4), 859-64, 2006

155. Hryszko T, Suzuki Y, Mogami H, Urano T.  Protein S attenuates the invasive potential of THP-1 cells by interfering with plasminogen binding on cell surface via a protein C-independent mechanism.  FEBS Letters 579(27), 6023-6, 2005

156. Nakamura R, Umemura K, Hashimoto H, Urano T. Less pronounced enhancement of thrombin-dependent inactivation of plasminogen activator inhibitor type 1 by low molecular weight heparin compared with unfractionated heparin.  Thromb Haemost 95, 637-42, 2006

157. Suzuki Y, Zhang H, Saito N, Urano T, Kojima N, Mogami H. Glucagon-Like Peptide 1 Activates Protein Kinase C Through a Ca2+-Dependent Phospholipase C Activation in Insulin-Secreting Cells.  J Biol Chem 281(39), 28499-28507, 2006

158. Suwa D, Konno H, Tanaka T, Urano T. Intraperitoneal Infusion of Recombinant Plasminogen Activator inhibitor Type 2 Induced Apoptosis in Implanted Human Colon Cancer and Inhibited its Growth and Liver Metastasis. Anticancer Research 28(2A), 693-698, 2008

159. Hayashi T, Mogami H, Murakami Y, Nakamura T, Kanayama N, Konno K, Urano T. Real-time analysis of platelet aggregation and procoagulant activity during thrombus formation in vivo. Pflugers Archiv-European Journal of Physiology 456(6), 1239-51, 2008

160. Suzuki Y, Mogami H, Ihara Y, Urano T. Unique secretory dynamics of tissue plasminogen activator and its modulation by plasminogen activator inhibitor-1 in vascular endothelial cells.  Blood 113, 470-478, 2009

161. Yashiro K, Matsumoto Y, Ihara H, Suzuki Y, Kondo K, Urano T, Umemura K. Involvement of platelet activation by P2Y12 receptor in the development of transplant arteriosclerosis in mice. Transplantation, 87(3), 660-667, 2009

162. Fujie M, Nakamura S, Asai K, Niimi T, Yamashita J, Kiyofuji K, Shibata K, Suzuki M, Aoshima R, Urano T and Yamashita M. A novel phospha sugar analogue: synthesis and evaluation of 2,3-dibromo- 3-methyl-1-phenylphospholane 1-oxide as a new class of potential panti-proliterative materials for leukemia cells. Heterocyclic Communications  15(4): 273-278, 2009

163. Tanaka A, Suzuki Y, Sugihara K, Kanayama N, Urano T. Inactivation of plasminogen activator inhibitor type 1 by activated factor XII plays a role in the enhancement of fibrinolysis by contact factors in-vitro. Life Scineces 85(5/6), 220-225, 2009

164. Hoki S, Suzuki Y, Umemura K, Urano T. Enhancement of fibrinolysis by gel-filtered platelets and its quenching by cytochalasin B and GPIIb/IIIa antagonists. Pharmacological Reports 61(5), 877-84, 2009

165. Adachi E, Kazoe Y, Sato Y, Suzuki Y, Urano T, Ueyama T, Saito N, Nikolaev VO, Lohse MJ, Tominaga M, Mogami H. A technique for monitoring multiple signals with a combination of prism-based total internal reflection fluorescence microscopy and epifluorescence microscopy Pflugers Arch - Eur J Physiol 459(1), 227-34, 2009

166. Suzuki, Y and Urano T. Novel mechanism of the expression and amplification of cell surface-associated fibrinolytic activity demonstrated by real-time imaging analysis. Journal Pharmacological Sciences 116(1), 19-24, 2011

167. Rybaltowski M, Suzuki Y, Mogami H, Chlebinska I, Brzoska T, Tanaka A, Banno F, Miyata T, Urano T. In vivo imaging analysis of the interaction between unusually large von-Willebrand factor multimers and platelets on the surface of vascular wall. Pflugers Arch - Eur J Physiol 461(6), 623-633, 2011

168. Iwaki T, Tanaka A, Miyawaki Y, Suzuki A, Kobayashi T, Takamatsu J, Matsushita T, Umemura K, Urano T, Kojima T, Terao T, Kanayama N. Life-threatening haemorrhage and prolonged wound healing are remarkable phenotypes manifested by complete PAI-1 deficiency in humans. Journal of Thrombosis and Haemostasis 9(6), 1200-1206, 2011

169. Suzuki Y, Yasui Y, Brzoska T, Mogami H, Urano T. Surface-retained tPA is essential for effective fibrinolysis on vascular endothelial cells. Blood 118(11), 3182-3185, 2011

170. Nishimura S, Manabe I, Nagasaki M, Kakuta S, Iwakura Y, Takayama N, Ooehara J, Otsu M, Kamiya A, Petrich B, Urano T, Kadono T, Sato S, Aiba A,  Yamashita H, Sugiura S, Kadowaki T, Nakauchi H, Eto K, and Nagai R. In vivo imaging visualizes discoid platelet aggregations without endothelium disruption and implicates contribution of inflammatory cytokine and integrin signaling. Blood 119(8): p. e45-56, 2012

171. Kramkowski K, Leszczynska A, Mogielnicki A, Chlopicki S, Fedorowicz A, Grochal E, Mann B, Brzoska T, Urano T, Motterlini R, Buczko W. Anti-thrombotic properties of water-soluble carbon monoxide-releasing molecules (CO-RMS). Arterioscler Thromb Vasc Biol 32, 2149-2157, 2012

172. Iwaki T, Urano T and Umemura K. PAI-1, progress in understanding the clinical problem and its aetiology. Br J Haematol, 157, 291-298, 2012

173. Urano T and Suzuki Y. Accelerated fibrinolysis and its propagation on vascular endothelial cells by secreted and retained tPA. J Biomed Biotechnol, Article ID 208108, 2012.

174. Brzoska T, Suzuki Y, Mogami H, Sano H, Urano T. Binding of thrombin-activated platelets to a fibrin scaffold through αIIbβ3 evokes phosphatidylserine exposure on their cell surface. Plos One, 8: E55466, 2013

175. Yasui H, Suzuki Y, Sano H, Suda T, Chida K, Dan T, Miyata T, Urano T. TM5275 prolongs secreted tissue plasminogen activator retention and enhances fibrinolysis on vascular endothelial cells. Thromb Res, 2013 Jul;132(1):100-5. doi: 10.1016/j.thromres.2013.04.003. Epub 2013 Apr 20.

 

Book & Review

1. Takada, A., Shirahama, S., Urano, T. and Takada, Y.   Mechanisms of interaction between complement and immunoglobulin.   In: Chemical Mediators of Inflamation and Immunity.   S. Cohen, H. Hayashi, K. Saito and A. Takada (eds)   Academic Press Japan, Inc. Tokyo, Japan pp. 101-128, 1986.

2. Castellino, F. J., Urano, T., Chibber, B. A. K. and de Serrano, V. S.   Anion  effects on the activation of human Glu-plasminogen.   In: Fibrinolysis - current prospects   P. J. Gaffney, F. J. Castellino, E. F. Plow and A. Takada. (eds)   John Libbey and Company Ltd., London, (1988) pp. 27-33.

3. Castellino, F. J., Urano, T., de Serrano, V. S. and Beals, J. M.   The structure and activation of human plasminogen.   In: Lipoprotein (a)   edited by Angleo M. Scanu.   Academic Press, Inc. San Diego, (1990)  pp87-90.

4. Takada, A., Urano, T. and Takada, Y.   Measurements of the concentrations of free plasminogen activator inhibitor 1 ans its complex with tissue plasminogen activator in human plasma.   In: Protease Inhibitors   edited by A. Takada, M. M. Samama and D. Collen.   Excerpta Meidca, Amsterdam, (1990)  pp49-59.

5. 5. Takada, Y. Urano, T. and Takada, A.   Variations of plasma levels of free PAI-1, t-PA-PAI-1 complex  and t-PA in human males and females at various ages.   In: Protease Inhibitors   edited by A. Takada, M. M. Samama and D. Collen.   Excerpta Meidca, Amsterdam, (1990)  pp147-154.

6. Urano, T., Takada, Y., Sakakibara, K., de Serrano, V. S., Castellino, F. J. and Takada, A.   Interaction between tissue plasminogen activator and fibrin(ogen).   In:Fibrinogen 4 ( Current basic and clinical aspects )   edited by M. Matsuda, S. Iwanaga, A. Takada and A. Henschen.   Elsevier Science Publishers B. V., (1990)  pp117-122.

7. Urano, S. Urano, Y. Takada and A. Takada.   Measurement of free PAI-1 level in the plasma and evaluation of its role in the euglobulin clot lysis time.   In: Recent Advances in Haemostasis and Cardiovascular Research  edited by Chung Yuan Liu and Shu Chien.   Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan, ROC. (1990) pp 1-6.

8. Urano, T., Takada, Y. and Takada, A. Effects of various N-terminal peptides of Glu-plasminogen on keeping its tight conformation of Glu-plasminogen.  In: Haemostasis and Circulation  edited by A. Takada and A.Z. Budzynski, Springer-Verlag, Tokyo, (1992) pp 103-108.

9. Takada, Y., Pietraszek, M.H., Urano, T. and Takada, A. Influences of mental stress on fibrinolysis, platelet aggregation and amines in plasma.  In: Haemostasis and Circulation  edited by A. Takada and A.Z. Budzynski, Springer-Verlag, Tokyo, (1992) pp 151-156.

10. Nagayama, M., Hayakawa, H., Sato, A., Urano, T., Takada, Y. and Takada, A.  Significance of plasminogen activators and plasminogen activator inhibitors in human lung cancer.  In: Haemostasis and Circulation  edited by A. Takada and A.Z. Budzynski, Springer-Verlag, Tokyo, (1992) pp 207-212.

11. Urano, T., Serizawa, K., Sakakibara, K., Strandberg, L., Ny, T., Takada, Y. and Takada, A.  The cleavage of a serine protease inhibitor at the reactive center by its target protease: Analysis of the substrate-like form of SERPIN.  In: Current aspects of blood coagulation, fibrinolysis, and platelets. edited by M.-C. Shen, C.-M. Teng and A. Takada  Springer-Verlag, Hong Kong, (1993) pp29-34.

12. Nishino, N., Nakamura, M., Konno, H., Baba, S., Aoki, K., Yonekawa, O., Hamada, E., Kanno, T., Takahashi, S., Cho, M., Urano, T., Takada, Y. and Takada, A.  Relation ships between the concentrations of u-PA, t-PA, PAI-1 and PAI-2 in tumor tissues and peritoneal washings, and tumor progression in gastric cancer.  In: Current aspects of blood coagulation, fibrinolysis, and platelets. edited by M.-C. Shen, C.-M. Teng and A. Takada  Springer-Verlag, Hong Kong, (1993) pp104-109.

13. Takada, Y., Urano, T., Takahashi, S., Sakakibara, K. and Takada, A.  Conformational change of Glu-plasminogen: Effects of N-terminal peptides of Glu-plasminogen.  In: Current aspects of blood coagulation, fibrinolysis, and platelets. edited by M.-C. Shen, C.-M. Teng and A. Takada  Springer-Verlag, Hong Kong, (1993) pp123-128.

14. Kozima, Y., Urano, T., Sakakibra, K., Serizawa, K., Takada, Y. and Takada, A.  Effect of calcium ion on the euglobulin clot lysis time: Significant shortening by physiological concentration of calcium ion.  In: Current aspects of blood coagulation, fibrinolysis, and platelets. edited by M.-C. Shen, C.-M. Teng and A. Takada  Springer-Verlag, Hong Kong, (1993) pp129-134.

15. Serizawa, K., Urano, T., Kozima, Y., Sakakibara, K., Takada, Y. and Takada, A.  The role of platelet PAI-1 in the platelet rich plasma clot lysis.  In: Current aspects of blood coagulation, fibrinolysis, and platelets. edited by M.-C. Shen, C.-M. Teng and A. Takada  Springer-Verlag, Hong Kong, (1993) pp135-139.

16. Yan, D., Urano, T., Takada, Y. and Takada, A.  The dissociation of a2-plasmin-inhibitor-plasmin complex to active plasmin by SDS treatment.  In: Current aspects of blood coagulation, fibrinolysis, and platelets. edited by M.-C. Shen, C.-M. Teng and A. Takada  Springer-Verlag, Hong Kong, (1993) pp140-146.

17. Sumiyoshi, K., Urano, T., Takada, Y and Takada, A.  PAI-1 and PAI-2 levels as predictors in staging malignancy in breast cancer.  In Fibrinolysis in disease: The malignant process, interventions in thrombogenic mechanisms and novel treatment modalities. edited by Pia Glas-Greenwalt  CRC Press, Boca Raton, USA, (1995)

18. Urano, T., Kojima, Y, Takada, Y., Ihara, H. and Takada, A. Euglobulin clot lysis time (ECLT): the evaluation of three independent mechanisms to initiate fibrinolysis by three alternative methods of ECLT.  In Blood Coagulation, Fibrinolysis, and Platelets. edited by E. W. Davie and E. Kakishita.  Springer Verlag, Tokyo, (1996)  pp 94-97

19. Takada, Y., Urano, T., Ihara, H., and Takada, Y.  Serotonergic functions of platelets of patients with diabetes mellitus.  In Blood Coagulation, Fibrinolysis, and Platelets. edited by E. W. Davie and E. Kakishita.  Springer Verlag, Tokyo, (1996)  pp 125-128

20. Urano, T., Nagai, N., Ihara, H., Takada, Y. and Takada A.  Calcium Ion Dependent Modulation of Fibrinolytic Activity.  In Recent Progress in Blood Coagulation and Fibrinolysis.  edited by A. Takada, D. Collen and P. Gaffney.  Elsevier, Tokyo, (1997) pp 67-73.

21. Takada, A. Urano, T. and Takada, Y.  Stress and hemostasis.   In Recent Progress in Blood Coagulation and Fibrinolysis.  edited by A. Takada, D. Collen and P. Gaffney.  Elsevier, Tokyo, (1997) pp 213-219.

22. Nagai, N. and Urano, T.  Role of tPA in the neural system. In Recent Advances in Thrombosis and Hemostasis. Edited by K. Tanaka and E.W. Davie. Springer, Tokyo, (2008) pp 314-327.

 

Lectures

  • 2002. 09 State of the Art Talk, 16th International Congress on Fibrinolysis and Proteolysis. “A mechanism of coagulation-associated enhancement of fibrinolysis and DIC: Pivotal role of activated coagulation factor dependent PAI-1 inactivation and its attenuation by aPC. Urano T, Munich, Germany
  •  
  • 2014. 07 Invited lecture “Regulatory mechanism of fibrinolytic activity in plasma and on vascular endothelial cells (VECs): Unique secretory dynamics of tissue plasminogen activator and the expression of its activity on VECs.” Urano T, Jagiellonian Centre for Experimental Therapeutics (JCET), Jagiellonian University, Krakow, Poland

 

Symposium

  • 2004. 10. 14 The 3rd Asian Pacific Congress on Thrombosis and Haemostasis, “Plasminogen activator inhibitor-1 (PAI-1): The key molecule to regulate fibrinolysis in the vasculature.” in Regulatory mechanism of coagulation and fibrinolysis. Urano T et al, Bangkok, Thailand
  • 2012. 12 HAA-APSTH2012-Annual Scientific Meeting “Cell-associated positive feedback mechanism of fibrinolysis.” Urano T, Melbourne, Australia
  • 2014. 02. Gordon Research Conference on Plasminogen Activation and Extracellular Proteolysis, “Regulatory Mechanism of the Expression of Plasmin Activity on Vascular Endothelial Cells Revealed by Imaging Technique” Urano T et al, Ventura, USA
  • 2014. 06. 60th Annual Meeting of the SSC, “Visualizing Plasmin Activity on Cell Surfaces” Urano T, Milwaukee, USA

 

Member of Society

  • Member of Japanese Society of Thrombosis and Haemostasis, 1983-
  •  (council member, 2012-)
  • Member of Japanese Society of Haematology, 1983-
  • Member of Japanese Society of Physiology, 1989-
  • Member of International Society of Fibrinolysis & Proteolysis, 1993-
  •       (council member, 2010-)
  • Member of International Society of Thrombosis and Haemostasis, 1996-
  •       (Co-chairman of Fibrinolysis division of SSC, 2009-2013)
  • Member of American Society of Hematology, 2001-

 

Editorial board

Editor of Japanese Journal of Thrombosis and Hemostasis, 2002-2004,

 (editor in chief) 2011-

Editor of Archives of Medical Science, 2007-

Regional Editor of Current Drug Targets, 2009-

Editor of Thrombosis Journal, 2013-

 

Ad-hoc Reviewer

Journal of Thrombosis and Haemostasis, Journal of Biological Chemistry, Circulation, Thrombosis and Haemostasis, Arteriosclerosis Thrombosis and Vascular Biology, Thrombosis Research, Journal of Pathology, Neuroscience Research, Cancer Letter, European Journal of Biochemistry,

 

Grants

  • Grant-in Aid for Scientific Research for young investigators (A) (No. 01770054) from the Ministry of Education, Science and Culture, Japan. 1989:  (Representative)
  • Grant-in Aid for Scientific Research (B) (No. 01480114) from the Ministry of Education, Science and Culture, Japan. 1989-91  contributory (representative: A. Takada)
  • Grant-in Aid for Scientific Research (C) No. 06670052 from the Ministry of Education, Science and Culture, Japan. 1994-95  (Representative)
  • Grant-in Aid for Scientific Research (C) (No. 62570040) from the Ministry of Education, Science and Culture, Japan. 1997-99  contributory (representative: A. Takada)
  • Grant-in Aid for Scientific Research (C) (No. 10670040) from the Ministry of Education, Science and Culture, Japan. 1998-2000 (Representative)
  • Grant-in Aid for Scientific Research (C) (No. 13670040) from the Ministry of Education, Science and Culture, Japan. 2001- 2003  (Representative)
  • Grant-in Aid for Scientific Research (No. 13670209) from the Japan Society for the Promotion of Science, Japan, 2002 – 2004  contributory (representative: H. Ihara)
  • Grant-in Aid for Scientific Research (No. 17590998) from the Japan Society for the Promotion of Science, Japan, 2005 – 2008  contributory (representative: H. Ihara)
  • Grant-in Aid for Scientific Research (No. 18590204) from the Japan Society for the Promotion of Science, Japan, 2006 – 200  (Representative)
  • Grant-in Aid for Scientific Research (No. 19590858) from the Japan Society for the Promotion of Science, Japan, 2007 – 2008   contributory (representative: Y. Suzuki)
  • Grant-in Aid for Scientific Research (No. 21590230) from the Japan Society for the Promotion of Science, Japan, 2009 – 201  (Representative)
  • Grant-in Aid for Scientific Research (No. 22590826) from the Japan Society for the Promotion of Science, Japan, 2010 – 2012  contributory (representative: Y. Suzuki)
  • Grant-in Aid for Scientific Research (No. 24590273) from the Japan Society for the Promotion of Science, Japan, 2012 – 2014  (Representative)
  • Grant-in Aid for Scientific Research (No. 24591420) from the Japan Society for the Promotion of Science, Japan, 2012 – 2014   contributory (representative: H. Sano)
  • Grant-in Aid for Scientific Research (No. 20345812) from the Japan Society for the Promotion of Science, Japan, 2013 – 2015    contributory (representative: Y. Suzuki)
  • Grant from the Smoking Research Foundation, Japan, 2006-2009  (Representative)
  • Grant from the Smoking Research Foundation, Japan, 2011-2013  (Representative)
  • Grant from the Smoking Research Foundation, Japan, 2014-  (Representative)

 

Japanese